Changes in serum copper and zinc during treatment with anticancer drugs interfering with pyridoxal phosphate.

  title={Changes in serum copper and zinc during treatment with anticancer drugs interfering with pyridoxal phosphate.},
  author={Milan Slavik and T. R. Narasimhan and Christopher M. Riley and Jana Slavik},
  journal={Advances in experimental medicine and biology},
Hexamethylmelamine, pentamethylmelamine and procarbazine are anticancer drugs known to interfere with pyridoxal phosphate. This paper presents results on copper and zinc serum levels during the treatment with each of these drugs used as single agents. Six NZW rabbits weighing 2.7-4.5 kg were used in these experiments. Hexamethylmelamine and procarbazine were administered by gastric gavage and pentamethylmelamine by intravenous route at the daily doses of 100 mg, 30 mg and 50 mg/kg of body… 
1 Citations
Clinical conditions altering copper metabolism in humans.
Overt copper deficiency is not believed to be a widespread public health concern for most population groups. However, a variety of case studies suggest that under certain circumstances, clinical


Changes in Serum Pyridoxal Phosphate Levels During Treatment with Anticancer Drugs a
Pyridoxal phosphate (PLP), the biologically active form of vitamin B,, is an important coenzyme in a number of biochemical reactions and its depletion may result in toxic and/or antitumor effects.
Changes in amino acid metabolism caused by 6-azauridine triacetate: relevance to cancer treatment.
  • M. Slavik
  • Chemistry, Medicine
    Cancer treatment reports
  • 1979
The results reveal that anticancer drugs other than amino acid analogs and amino acid-depleting enzymes may cause significant changes in amino acid metabolism and can be used as an alternative method for studying the relevance of amino acid changes to the treatment of cancer.
Hexamethylmelamine. An evaluation of its role in the therapy of cancer
Clinical evidence suggests a lack of cross‐resistance between HMM and alkylating agents and its activity as a single agent in tumors such as those of the bladder, prostate, and uterus, and in combination chemotherapy in lymphomas, and mammary, cervical, and pulmonary tumors is warranted.
Changes in serum and urine amino acids in patients with progressive systemic sclerosis treated with 6-azauridine triacetate.
Abstract Homocystine, β-alanine and significant elevations of methionine, threonine and histidine were found in the serum of seven patients with progressive systemic sclerosis as a result of
Chromomycin A3, mithramycin, and olivomycin: antitumor antibiotics of related structure.
This chapter discusses the three anticancer antibiotics—namely, chromomycin A 3 , mithramycin, and olivomycin, which are aureolic acid analogs developed independently in three countries— Japan, the United States, and USSR.
Hyperaminoacidemia in rabbits treated with 6-azauridine triacetate.
Abstract The administration of 6-azauridine triacetate to rabbits results in the appearance of homocystine, homocysteine-cysteine disulphide, β-aminoisobutyric acid, and an elevation of cystathionine