Changes in serum concentrations of soluble vascular endothelial growth factor receptor-1 after pregnancy.

@article{Wathn2011ChangesIS,
  title={Changes in serum concentrations of soluble vascular endothelial growth factor receptor-1 after pregnancy.},
  author={Katja-Anneli Wath{\'e}n and Jaakko Sarvela and F Stenman and U Stenman and Piia Vuorela},
  journal={Human reproduction},
  year={2011},
  volume={26 1},
  pages={221-6}
}
BACKGROUND Vascular endothelial growth factor (VEGF) is the most potent stimulator of angiogenesis. It mediates its activity through two membrane-bound receptors, VEGFR-1 and VEGFR-2, both expressed in the placenta. Beginning in early pregnancy, the soluble form of the first, sVEGFR-1, binds and inhibits most of the biological actions of circulating VEGF. After delivery, it disappears from the maternal circulation. METHODS We determined the biological elimination rate of endogenous sVEGFR-1… CONTINUE READING
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