Changes in self-reactive IgG antibody repertoire after treatment of experimental autoimmune encephalomyelitis with anti-allergic drugs.

@article{Behi2007ChangesIS,
  title={Changes in self-reactive IgG antibody repertoire after treatment of experimental autoimmune encephalomyelitis with anti-allergic drugs.},
  author={Mohamed El Behi and H{\'e}l{\`e}ne Z{\'e}phir and Didier Lefranc and Virginie Dutoit and Patricia Dussart and Patrick Devos and Jean Paul Dessaint and Patrick Vermersch and Lionel Prin},
  journal={Journal of neuroimmunology},
  year={2007},
  volume={182 1-2},
  pages={80-8}
}
We reduced EAE severity by using two anti-allergic drugs. A control group of mice received i.p. injections of PBS as vehicle while a further two groups were treated either with pyrilamine, a histamine receptor 1 antagonist or with CV6209, a platelet activating factor receptor antagonist. Our results showed that the blockade of the responses to both histamine and PAF leads together to a decline in clinical signs of EAE and significant changes in the serum IgG recognition of some healthy brain… CONTINUE READING