Changes in ryanodine receptor-mediated calcium release during skeletal muscle differentiation.

@article{Wingertzahn1999ChangesIR,
  title={Changes in ryanodine receptor-mediated calcium release during skeletal muscle differentiation.},
  author={Mark A. Wingertzahn and Raymond S. Ochs},
  journal={Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine},
  year={1999},
  volume={221 3},
  pages={234-41}
}
We have observed a disparity between the actions of caffeine and ryanodine, two agents known to affect the same site of intracellular calcium (Ca2+) release in muscle. The site of intracellular Ca2+ release, the ryanodine receptor (RyR), is established as the route of Ca2+ movement from the sarcoplasmic reticulum (SR) to the cytosol during excitation-contraction coupling. We measured Ca2+ release fluorimetrically in both saponin-permeabilized and intact L6 cells, in response to known modulators… CONTINUE READING