Changes in renal hemodynamics and structure in the aging kidney; sexual dimorphism and the nitric oxide system

@article{Baylis2005ChangesIR,
  title={Changes in renal hemodynamics and structure in the aging kidney; sexual dimorphism and the nitric oxide system},
  author={Chris Baylis},
  journal={Experimental Gerontology},
  year={2005},
  volume={40},
  pages={271-278}
}
With advancing age the kidney shows both functional declines (falls in GFR) and development of structural damage. In most individuals this occurs slowly and does not lead to severe renal impairment unless additional insults are superimposed. There is a pronounced sexual dimorphism with females protected, due both to beneficial effects of the estrogens and damaging effects of androgens, some of which act directly on the glomerular mesangial cell to regulate growth and extracellular matrix… CONTINUE READING

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