Changes in relative potency among positive GABAA receptor modulators upon discontinuation of chronic benzodiazepine treatment in rhesus monkeys

@article{McMahon2006ChangesIR,
  title={Changes in relative potency among positive GABAA receptor modulators upon discontinuation of chronic benzodiazepine treatment in rhesus monkeys},
  author={Lance R. McMahon and Martin A. Javors and Charles P France},
  journal={Psychopharmacology},
  year={2006},
  volume={192},
  pages={135-145}
}
Benzodiazepine treatment can result in dependence as evidenced by signs of withdrawal upon discontinuation of use. Positive GABAA receptor modulators were examined for their capacity to attenuate flumazenil-like discriminative stimulus effects (i.e., withdrawal) that emerge upon discontinuation of chronic benzodiazepine treatment. Rhesus monkeys receiving chronic diazepam (5.6 mg−1 kg−1 24 h−1 p.o.) discriminated flumazenil (0.1 mg/kg s.c.) from vehicle. Upon discontinuation of diazepam… CONTINUE READING