Changes in purine metabolism and production of oxygen free radicals by intermittent partial umbilical cord occlusion in chronically instrumented fetal lambs.

@article{Masaoka1998ChangesIP,
  title={Changes in purine metabolism and production of oxygen free radicals by intermittent partial umbilical cord occlusion in chronically instrumented fetal lambs.},
  author={Naoki Masaoka and Yasuhito Hayakawa and Sachiko Ohgame and Hisaei Sakata and Kodo Satoh and H Takahashi},
  journal={The journal of obstetrics and gynaecology research},
  year={1998},
  volume={24 1},
  pages={63-71}
}
OBJECTIVE Undetected umbilical-cord compression has been suggested to be implicated in unexplained fetal brain damage. We tested the hypothesis that the generation of oxygen-free radicals (OFRs) during intermittent partial umbilical cord occlusion might play a causal role in antenatal CNS injury. METHODS Using 7 established chronically instrumented fetal lambs, intermittent partial occlusion of the umbilical circulation was produced according to the method of Clapp et al. for 1 of every 3… CONTINUE READING