Changes in pulmonary blood flow affect vascular response to chronic hypoxia in rats.

@article{Rabinovitch1983ChangesIP,
  title={Changes in pulmonary blood flow affect vascular response to chronic hypoxia in rats.},
  author={Marlene Rabinovitch and Marvin A. Konstam and Walter J Gamble and Nicholas Papanicolaou and Mark J. Aronovitz and S. T. Treves and Lynne Reid},
  journal={Circulation research},
  year={1983},
  volume={52 4},
  pages={432-41}
}
We banded the left pulmonary artery in rats to investigate, in the same animal, the effect of both increased and decreased flow on the lung vasculature and to determine how these hemodynamic states modify the structural changes produced by a 2-week exposure to hypobaric hypoxia. In unanesthetized rats, pressures were recorded from the main pulmonary artery and aorta via indwelling catheters, cardiac output was calculated by the Fick principle, and pulmonary and systemic vascular resistance… CONTINUE READING