Changes in proteoglycans of human osteoarthritic cartilage maintained in explant culture: implications for understanding repair in osteoarthritis.

Abstract

The maintenance of human osteoarthritic femoral head cartilage in long-term explant culture has been used to assess changes in newly synthesized and endogenous proteoglycans. Minced cartilage was radiolabeled with [3H]-leucine for 24 h. and the high density proteoglycans digested with tosyl-phenylalanine chloromethyl ketone-trypsin. Chondroitin-sulfate-rich… (More)

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@article{Malemud1988ChangesIP, title={Changes in proteoglycans of human osteoarthritic cartilage maintained in explant culture: implications for understanding repair in osteoarthritis.}, author={Charles J. Malemud and R Shuckett and Victor M. Goldberg}, journal={Scandinavian journal of rheumatology. Supplement}, year={1988}, volume={77}, pages={7-12} }