Changes in protein kinase C isoenzyme expression associated with apoptosis in U937 myelomonocytic cells.

@article{Pongrcz1995ChangesIP,
  title={Changes in protein kinase C isoenzyme expression associated with apoptosis in U937 myelomonocytic cells.},
  author={Judit E. Pongr{\'a}cz and W. Tuffley and G. D. Johnson and Elizabeth M Deacon and David L Burnett and Robert Andrew Stockley and Janet M. Lord},
  journal={Experimental cell research},
  year={1995},
  volume={218 2},
  pages={430-8}
}
Spontaneously apoptotic U937 cells from exponentially growing cell cultures were enriched on discontinuous Percoll density gradients. Increased PKC-beta and reduced PKC-zeta expression were detected in apoptotic cells by Western blotting. Using confocal microscopy, changes in the level of PKC isoenzymes were confirmed and in addition alterations in the subcellular location of PKC isoenzymes were detected in apoptotic cells compared with nonapoptotic cells. The data indicate that the expression… CONTINUE READING

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