Changes in protein expression and distribution of spinal CCR2 in a rat model of bone cancer pain.

@article{Hu2013ChangesIP,
  title={Changes in protein expression and distribution of spinal CCR2 in a rat model of bone cancer pain.},
  author={Ji-Hua Hu and Meng-Yao Wu and Min Tao and Jianping Yang},
  journal={Brain research},
  year={2013},
  volume={1509},
  pages={1-7}
}
Accumulating evidence suggests that chemokine C-C motif receptor 2 (CCR2) plays an important role in neuropathic pain. It has been shown that spinal CCR2 is upregulated in several neuropathic pain models and expressed by neuronal and glial cells in the spinal cord. In this study, we investigated the expression changes and cellular localization of spinal CCR2 in a rat model of bone cancer induced by Walker 256 cell inoculation. The present results indicated that mechanical allodynia… CONTINUE READING