Corpus ID: 17021590

Changes in plasma methionine and total homocysteine levels in patients receiving methotrexate infusions.

@article{Broxson1989ChangesIP,
  title={Changes in plasma methionine and total homocysteine levels in patients receiving methotrexate infusions.},
  author={E. Broxson and L. Stork and R. Allen and S. Stabler and J. F. Kolhouse},
  journal={Cancer research},
  year={1989},
  volume={49 21},
  pages={
          5879-83
        }
}
Methotrexate reduces intracellular pools of 5-methyltetrahydrofolate and could result in reduced conversion of homocysteine to methionine by methionine synthetase. This study was designed to investigate the effects of moderate dose to very high dose methotrexate on methionine and total homocysteine as reflections of methotrexate induced intracellular events. Methionine and total homocysteine were measured prior to, during, and following twenty-six 24-h i.v. infusions of 33.6 g/m2 methotrexate… Expand
Low-Dose Methotrexate Inhibits Methionine S-Adenosyltransferase In Vitro and In Vivo
Homocysteine, pharmacogenetics, and neurotoxicity in children with leukemia.
  • S. Kishi, J. Griener, +8 authors M. Relling
  • Medicine
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2003
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Acute and long-term effects of high-dose methotrexate treatment on homocysteine in plasma and urine.
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Systemic clearance of methotrexate in the prognosis of acute lymphoblastic leukemia in children
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