Changes in pH differently affect the binding properties of histamine H1 receptor antagonists.

@article{Gillard2006ChangesIP,
  title={Changes in pH differently affect the binding properties of histamine H1 receptor antagonists.},
  author={Michel Gillard and P. Chatelain},
  journal={European journal of pharmacology},
  year={2006},
  volume={530 3},
  pages={
          205-14
        }
}
We investigated the effect of acidic pH, a condition that can be encountered during inflammation accompanying allergic reaction, on the binding properties of histamine H1 receptor antagonists, including levocetirizine ((2-(4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl)ethoxy)acetic acid; Xyzal ), fexofenadine (rac-2-[4-[1-Hydroxy-4-[4-(hydroxydiphenylmethyl) piperidin-1-yl]butyl]phenyl]-2-methylpropionic acid hydrochloride; Allegra) and desloratadine (8-Chloro-6,11-dihydro-11-(4… CONTINUE READING
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