Changes in pH and blood flow induced by glucose, and their effects on hyperthermia with or without BCNU in RIF-1 tumours.

@article{Hiraoka1990ChangesIP,
  title={Changes in pH and blood flow induced by glucose, and their effects on hyperthermia with or without BCNU in RIF-1 tumours.},
  author={Masahiro Hiraoka and George M. Hahn},
  journal={International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group},
  year={1990},
  volume={6 1},
  pages={
          97-103
        }
}
  • M. Hiraoka, G. Hahn
  • Published 1990
  • Medicine, Biology
  • International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
The changes in pH and blood flow of tumours caused by hyperglycaemia, and their effects on hyperthermia with BCNU, were investigated using RIF-1 tumours which grew intradermally in the thigh of C3H mice. The pH of the tumour was measured by inserting a microelectrode into the tumour. The blood flow in the tumour was estimated by flow cytometry from the uptake of the bisbenzamide fluorochrome Hoechst 33342 into the tumour. Administration of glucose resulted in a transient drop of both pH and… 
Antitumour effect of irradiation followed by hyperglycemia and hyperthermia: the dependence on tumour size and blood flow.
  • S. Kozin, A. Zaitsev, S. P. Yarmonenko
  • Medicine, Biology
    International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
  • 1996
TLDR
Postirradiation blood flow inhibition plays a significant role in the tumouricidal effect of irradiation with HG and HT, and the monitoring of tumour perfusion may be useful for the prediction of the effectiveness of such postirradiated modification, which is especially attractive in radiotherapy of large advanced tumours.
Laser Doppler flux and tissue oxygenation of experimental tumours upon local hyperthermia and/or hyperglycaemia
TLDR
It is concluded that under hyperglycaemia the oxygenation status of normothermic and heated tumours is maintained and it may be hypothesized that hyperthermia in conjunction with hyper glycaemia might be a better “radiosensitizer” thanhyperthermia alone.
Human tumor extracellular pH as a function of blood glucose concentration.
Effect of hypertonic glucose in thermotolerant rat BT4An gliomas treated with combined hyperthermia and BCNU in vivo.
  • B. Schem, O. Mella, S. Roszinski, O. Dahl
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TLDR
Glucose administered before treatment of thermotolerant tumours did not change the growth rate of tumours treated with hyperthermia, BCNU, or thermochemotherapy with a low or high dose BCnU, in contrast to previous results, where glucose enhanced thermochemosensitivity of non-thermotolerants tumours.
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  • Medicine, Biology
    International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
  • 2006
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The most important physiological parameter influencing tissue response to heat is blood flow and decreasing blood flow, using transient physiological modifiers or longer acting vascular disrupting agents prior to the initiation of heating, can both increase the accumulation of physical heat in the tumour, as well as increase heat sensitivity.
Effect of i.v. glucose versus combined i.v. plus oral glucose on human tumour extracellular pH for potential sensitization to thermoradiotherapy.
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Effects of Tumor Necrosis Factor and Hyperthermia on Meth‐A Tumors
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