Changes in oxygenated hemoglobin link freezing of gait to frontal activation in patients with Parkinson disease: an fNIRS study of transient motor-cognitive failures

@article{Maidan2015ChangesIO,
  title={Changes in oxygenated hemoglobin link freezing of gait to frontal activation in patients with Parkinson disease: an fNIRS study of transient motor-cognitive failures},
  author={Inbal Maidan and Hagar Bernad-Elazari and Eran Gazit and Nir Giladi and Jeffery M. Hausdorff and Anat Mirelman},
  journal={Journal of Neurology},
  year={2015},
  volume={262},
  pages={899-908}
}
Recent studies have suggested that deficits in executive function contribute to freezing of gait (FOG), an episodic disturbance common among patients with Parkinson’s disease (PD). To date, most findings provide only indirect evidence of this relationship. Here, we evaluated a more direct link between FOG and frontal lobe dysfunction. Functional, near infrared spectroscopy measured frontal activation, i.e., oxygenated hemoglobin (HbO2) levels in Brodmann area 10 before and during FOG. Eleven… CONTINUE READING

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