Changes in nociception, arterial blood pressure and heart rate produced by intravenous morphine in the conscious rat

@article{Thurston1993ChangesIN,
  title={Changes in nociception, arterial blood pressure and heart rate produced by intravenous morphine in the conscious rat},
  author={Cindy L. Thurston and A. Starnes and Alan Randich},
  journal={Brain Research},
  year={1993},
  volume={612},
  pages={70-77}
}
The present study shows that intravenous (i.v.) administration of morphine produces dose-dependent increases in tail flick and hot plate latencies in conscious rats. I.v. morphine also decreased heart rate, but had no significant effects on arterial blood pressure. Transection of the right vagus at the cervical level or pre-treatment with the peripherally acting opioid receptor antagonist naloxone methobromide attenuated the increased tail flick latency produced by either 1.75 or 2.5 mg/kg… CONTINUE READING
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Animal models of nociception.

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