Changes in nicotinic and muscarinic cholinergic receptors in Alzheimer-type dementia.

@article{Shimohama1986ChangesIN,
  title={Changes in nicotinic and muscarinic cholinergic receptors in Alzheimer-type dementia.},
  author={Shun Shimohama and Takanobu Taniguchi and Michihiro Fujiwara and Masakuni Kameyama},
  journal={Journal of neurochemistry},
  year={1986},
  volume={46 1},
  pages={288-93}
}
Nicotinic and muscarinic cholinergic receptors were studied in autopsied brains from four histologically normal controls and five histopathologically verified cases of Alzheimer-type dementia (ATD), using ligand binding techniques. Nicotinic and muscarinic cholinergic receptors were assessed by (-)-[3H]nicotine and [3H]quinuclidinyl benzilate [( 3H]QNB), respectively. Compared with the controls, (-)-[3H]nicotine binding sites in the ATD brain regions examined were significantly reduced in the… CONTINUE READING