Changes in nicotinic acetylcholine receptor subunits expression in brain of patients with Down syndrome and Alzheimer's disease.

@article{Engidawork2001ChangesIN,
  title={Changes in nicotinic acetylcholine receptor subunits expression in brain of patients with Down syndrome and Alzheimer's disease.},
  author={Ephrem Engidawork and Talin Gulesserian and Nadja Balic and Nigel J. Cairns and Gert Lubec},
  journal={Journal of neural transmission. Supplementum},
  year={2001},
  volume={61},
  pages={211-22}
}
Cholinergic deficit associated with loss of nicotinic acetylcholine receptors (nAChRs) has been described in Alzheimer's disease (AD) by receptor binding assays, positron emission tomography and immunoblotting. However, little is known about the alteration of these receptors in a related disease, Down syndrome (DS) which might be of importance for therapeutic strategies. The protein levels of neuronal nAChR alpha and beta subunits in human postmortem brain samples (frontal cortex and cerebellum… CONTINUE READING

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