Changes in n-6 and n-3 polyunsaturated fatty acids during lipid-peroxidation of mitochondria obtained from rat liver and several brain regions: effect of alpha-tocopherol.

@article{Zanetti2000ChangesIN,
  title={Changes in n-6 and n-3 polyunsaturated fatty acids during lipid-peroxidation of mitochondria obtained from rat liver and several brain regions: effect of alpha-tocopherol.},
  author={R. Zanetti and {\'A}. Catala},
  journal={Prostaglandins, leukotrienes, and essential fatty acids},
  year={2000},
  volume={62 6},
  pages={
          379-85
        }
}
  • R. Zanetti, Á. Catala
  • Published 2000
  • Biology, Medicine
  • Prostaglandins, leukotrienes, and essential fatty acids
The effect of intraperitoneal administration of alpha-tocopherol (100 mg/kg weight/24 h) on ascorbate (0-0.4 mM) induced lipid peroxidation of mitochondria isolated from rat liver, cerebral hemispheres, brain stem and cerebellum was examined. The ascorbate induced light emission in hepatic mitochondria was nearly completely inhibited by alpha-tocopherol (control-group: 114.32+/-14.4; vitamin E-group: 17.45+/-2.84, c.p.m.x10(-4)). In brain mitochondria, 0.2 mM ascorbate produced the maximal… Expand
Protective effect of melatonin on ascorbate‐Fe2+ lipid peroxidation of polyunsaturated fatty acids in rat liver, kidney and brain microsomes: a chemiluminescence study
TLDR
Results indicate a selective protection of C20:4 n6 and C22:6 n3 by melatonin during non‐enzymatic lipid peroxidation of rat liver, kidney and brain microsomes. Expand
Sensitivity of mitochondria isolated from liver and kidney of rat and bovine to lipid peroxidation: A comparative study of light emission and fatty acid profiles
TLDR
The results suggest that mainly the PUFAs present in hepatic and kidney mitochondria were sensitive to oxidative damage, and the lipid peroxidation process was more effective in rat liver mitochondria than in bovine. Expand
Non-enzymatic and enzymatic lipid peroxidation of microsomes and nuclei obtained from rat liver
TLDR
The results indicate that non-enzymatic and enzymatic lipid peroxidation are operative in rat liver microsomes and nuclei but the sensitivities of both organelles to lipidperoxidation evidenced by chemiluminescence was greater in the presence of ascorbate-Fe2+ when compared with NADPH. Expand
Roles of unsaturated fatty acids (especially omega-3 fatty acids) in the brain at various ages and during ageing.
  • J. Bourre
  • Medicine
  • The journal of nutrition, health & aging
  • 2004
TLDR
Recent results have shown that dietary alpha-linolenic acid deficiency induces more marked abnormalities in certain cerebral structures than in others, as the frontal cortex and pituitary gland are more severely affected. Expand
Analysis of age-associated changes in mitochondrial free radical generation by rat testis
TLDR
The data suggest that ageing is accompanied by reduced activity of SOD, leading to excessive oxidative stress and enhanced lipid peroxidation that compromises the functionality of the electron transport chain, and support the concept that mitochondrial function is an important determinant in ageing. Expand
An overview of lipid peroxidation with emphasis in outer segments of photoreceptors and the chemiluminescence assay.
  • Á. Catala
  • Chemistry, Medicine
  • The international journal of biochemistry & cell biology
  • 2006
TLDR
The author proposes the outer segments of photoreceptors as an excellent model to study lipid peroxidation using the chemiluminescence assay since these membranes contain the highest concentration of polyunsaturated fatty acids of any vertebrate tissue and are highly susceptible to oxidative damage. Expand
Five Decades with Polyunsaturated Fatty Acids: Chemical Synthesis, Enzymatic Formation, Lipid Peroxidation and Its Biological Effects
TLDR
This review is intended to cover some of the most important aspects of this work on polyunsaturated fatty acids and the effect of many antioxidants such as alpha tocopherol, vitamin A, melatonin and its structural analogues, and conjugated linoleic acid, among others. Expand
Docosahexaenoic Acid Abundance in the Brain: A biodevice to Combat Oxidative Stress
TLDR
A neuroprotective role for DHA, possibly in association with the vinyl ether (VE) linkage of plasmalogens (pPLs) in combating free radicals is proposed. Expand
Lethal dysregulation of energy metabolism during embryonic vitamin E deficiency
ABSTRACT Vitamin E (&agr;‐tocopherol, VitE) was discovered in 1922 for its role in preventing embryonic mortality. We investigated the underlying mechanisms causing lethality using targetedExpand
Age-related structural and functional changes of brain mitochondria.
TLDR
This article reviews some of the major structural and functional changes in mitochondria associated with ageing and proposes that there are important differences between normal ageing and neurodegeneration. Expand
...
1
2
...

References

SHOWING 1-10 OF 15 REFERENCES
Release of ethane and pentane from rat tissue slices: effect of vitamin E, halogenated hydrocarbons, and iron overload.
TLDR
Total ethane and pentane released from the slices was as reliable as and more sensitive than thiobarbituric acid-reactive substances as an index of lipid peroxidation. Expand
The composition of alkanes in exhaled air of rats as a result of lipid peroxidation in vivo. Effects of dietary fatty acids, vitamin E and selenium.
TLDR
The results strongly suggest that the alkanes produced as a result of lipid peroxidation in vivo originate from the methyl end of the fatty acid administered. Expand
Effect of High Doses of Dietary Vitamin E on the Concentrations of Vitamin E in Several Brain Regions, Plasma, Liver, and Adipose Tissue of Rats
TLDR
Brain levels of α‐tocopherol were somewhat resistant to vitamin E deficiency, in contrast to the peripheral tissues, as observed before. Expand
Phospholipid fatty acid composition and vitamin E levels in the retina of obese (fa/fa) and lean (FA/FA) Zucker rats.
TLDR
Modifications of phospholipid fatty acid composition which have previously been reported in peripheral tissues of obese Zucker rats also affect the retina, suggesting differences in the tissue antioxidant status between these two genotypes. Expand
Dietary vitamin E decreases ESR signal intensity in hepatic microsomal preparations from malignant hyperthermia susceptible pigs.
TLDR
Vitamin E supplementation may decrease the peroxidative events associated with MH and Elevated pyruvate kinase activities and TBARS concentrations in plasma of MHS pigs were moderated by dietary vitamin E. Expand
Vitamin E: interactions with free radicals and ascorbate.
  • P. McCay
  • Chemistry, Medicine
  • Annual review of nutrition
  • 1985
TLDR
It seems clear that the biological function of this vitamin is not specific in the sense of its being a cofactor for an enzymic reaction (as is the case for the B-complex vitamins), and essentially any tissue can be made to develop characteristic signs as a result of a deficiency of this vitamins. Expand
The relationship between chemiluminescence and lipid peroxidation in rat hepatic microsomes.
TLDR
The results of these experiments indicate that chemiluminescence initiated in hepatic microsomes by either NADPH or ascorbate is directly proportional to lipid peroxidation. Expand
Lipid peroxidation in mitochondrial membrane.
TLDR
The process of lipid peroxidation might be specific in many respects to each particular membrane formation in given types of cells, though there are some general features of this phenomenon intrinsic to any membrane structure in any cell. Expand
Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria.
TLDR
An O2- -dependent autocatalytic process that requires NADH, submitochondrial particles and adrenaline is described. Expand
Oxidants in mitochondria: from physiology to diseases.
TLDR
It is concluded that ROS and NO are important physiological reactants in mitochondria and become toxic only when present in excessive amounts. Expand
...
1
2
...