Changes in muscle fibre type, muscle mass and IGF-I gene expression in rabbit skeletal muscle subjected to stretch.

@article{Yang1997ChangesIM,
  title={Changes in muscle fibre type, muscle mass and IGF-I gene expression in rabbit skeletal muscle subjected to stretch.},
  author={Hui Yang and Majed A. Alnaqeeb and H. Mitchell Simpson and Geoffrey Goldspink},
  journal={Journal of anatomy},
  year={1997},
  volume={190 ( Pt 4)},
  pages={613-22}
}
The relationship between IGF-1 and changes in muscle fibre phenotype in response to 6 d of stretch or disuse of the lower limb muscles of the rabbit was studied by combining in situ hybridisation and immunohistochemistry procedures. Passive stretch by plaster cast immobilisation of the muscle in its lengthened position not only induced an increase in IGF-I mRNA expression within the individual muscle fibres but also an increase in the percentage of fibres expressing neonatal and slow myosin… CONTINUE READING

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