Changes in motor innervation and cholinesterase localization induced by botulinum toxin in skeletal muscle of the mouse: differences between fast and slow muscles.

@article{Duchen1970ChangesIM,
  title={Changes in motor innervation and cholinesterase localization induced by botulinum toxin in skeletal muscle of the mouse: differences between fast and slow muscles.},
  author={L. W. Duchen},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  year={1970},
  volume={33 1},
  pages={40-54}
}
  • L. W. Duchen
  • Published 1970 in
    Journal of neurology, neurosurgery, and…
Botulinum toxin causes paralysis of skeletal muscle by preventing the release of acetylcholine at motor nerve terminals (Burgen, Dickens, and Zatman, 1949). It is known that, when a sub-lethal quantity of toxin is injected directly into muscles of experimental animals, paralysis and atrophy of those muscles develop and persist for a long time (Guyton and MacDonald, 1947; Jirmanova, Sobotkova, Thesleff, and Zelena, 1964; Duchen and Strich, 1967, 1968). A remarkable overgrowth of motor nerve… CONTINUE READING

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Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine • 1949
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