Changes in motor cortex inhibition over time in patients with amyotrophic lateral sclerosis

@article{Zanette2002ChangesIM,
  title={Changes in motor cortex inhibition over time in patients with amyotrophic lateral sclerosis},
  author={Giampietro Zanette and Stefano Tamburin and Paolo Manganotti and Nicola Refatti and Antonio Forgione and Nicol{\'o} Rizzuto},
  journal={Journal of Neurology},
  year={2002},
  volume={249},
  pages={1723-1728}
}
Abnormal balance between intracortical inhibitory and excitatory mechanisms has been found to contribute to the genesis of motor cortex hyperexcitability in amyotrophic lateral sclerosis (ALS), but data are lacking on the role of these abnormalities in the pathophysiology of the disease. We evaluated the resting motor threshold (RMT), the cortical silent period (CSP) to single-pulse transcranial magnetic stimulation (TMS), early intracortical inhibition (ICI), early intracortical facilitation… CONTINUE READING

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