Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis.

@article{Parra2008ChangesIM,
  title={Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis.},
  author={Vega Rodr{\'i}guez-Flores Parra and Ver{\'o}nica Eisner and Mario Chiong and Alfredo Criollo and Francisco Javier Vesperinas Moraga and Alejandra Garcia and S. L. C. Haertel and Enrique Jaimovich and Antonio Zorzano and Carmen Robina Hidalgo and Sergio Lavandero},
  journal={Cardiovascular research},
  year={2008},
  volume={77 2},
  pages={
          387-97
        }
}
AIMS In cells, mitochondria are organized as a network of interconnected organelles that fluctuate between fission and fusion events (mitochondrial dynamics). This process is associated with cell death. We investigated whether activation of apoptosis with ceramides affects mitochondrial dynamics and promotes mitochondrial fission in cardiomyocytes. METHODS AND RESULTS Neonatal rat cardiomyocytes were incubated with C(2)-ceramide or the inactive analog dihydro-C(2)-ceramide for up to 6 h… CONTINUE READING

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