Changes in microtubules and microfilaments due to a combined effect of ultrasound and cytostatics in HeLa cells.

@article{korpkov2001ChangesIM,
  title={Changes in microtubules and microfilaments due to a combined effect of ultrasound and cytostatics in HeLa cells.},
  author={Jiřina {\vS}korp{\'i}kov{\'a} and M Doln{\'i}kov{\'a} and Ivo Hrazdira and Roman Janisch},
  journal={Folia biologica},
  year={2001},
  volume={47 4},
  pages={143-7}
}
Treatment of HeLa cells with low intensity ultrasound and two cytostatic drugs, cycloplatin and methotrexate, resulted in a partial disassembly of microtubules and microfilaments. This disassembly was due to depolymerization and subsequent erroneous repolymeration of essential cytoskeletal proteins, resulting in formation of unusual arrangements, mainly small, granule-like structures. The combined action of ultrasound and cytostatics had a synergistic effect dependent on both the concentration… CONTINUE READING