Changes in microtubule turnover accompany synaptic plasticity and memory formation in response to contextual fear conditioning in mice

@article{Fanara2010ChangesIM,
  title={Changes in microtubule turnover accompany synaptic plasticity and memory formation in response to contextual fear conditioning in mice},
  author={Patrizia Fanara and Kristofor H Husted and Karolin Selle and Pik-fan. Wong and Jineta Banerjee and Roland Brandt and Marc K. Hellerstein},
  journal={Neuroscience},
  year={2010},
  volume={168},
  pages={167-178}
}
Synaptic plasticity plays a crucial role in learning, memory, and cognitive disorders. Cytoskeletal reorganization underlies neuronal synaptic plasticity, but little is known about the regulation of cytoskeletal dynamics in living animals. We used stable isotope labeling to measure the turnover of tubulin in defined microtubule (MT) populations in murine brain. Neuronal MTs generally exhibited low turnover rates in vivo. Basal turnover was highest in tau-associated MTs, intermediate in… CONTINUE READING
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