Changes in microRNAs associated with hepatic stellate cell activation status identify signaling pathways.

@article{Guo2009ChangesIM,
  title={Changes in microRNAs associated with hepatic stellate cell activation status identify signaling pathways.},
  author={Can-jie Guo and Qin Feng Pan and Tao Cheng and Bo Jiang and Guang-yu Chen and Ding-guo Li},
  journal={The FEBS journal},
  year={2009},
  volume={276 18},
  pages={
          5163-76
        }
}
Activation of hepatic stellate cells (HSCs), which is regulated by multiple signal transduction pathways, is the key event in liver fibrosis. Moreover, members of these pathways are important targets for microRNAs (miRNAs). To better understand the critical pathways of HSC activation, we performed comprehensive comparative bioinformatics analysis of microarrays of quiescent and activated HSCs. Changes in miRNAs associated with HSC activation status revealed that 13 pathways were upregulated and… CONTINUE READING
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