Changes in methacholine induced bronchoconstriction with the long acting beta 2 agonist salmeterol in mild to moderate asthmatic patients.

@article{Booth1993ChangesIM,
  title={Changes in methacholine induced bronchoconstriction with the long acting beta 2 agonist salmeterol in mild to moderate asthmatic patients.},
  author={Helen Booth and Kevin Fishwick and R Harkawat and Graham Devereux and David J Hendrick and E. Haydn Walters},
  journal={Thorax},
  year={1993},
  volume={48 11},
  pages={1121-4}
}
BACKGROUND Beta-2 agonists protect against non-specific bronchoconstricting agents such as methacholine, but it has been suggested that the protection afforded by long acting beta 2 agonists wanes rapidly with regular treatment. METHODS The changes in airway responsiveness were investigated during and after eight weeks of regular treatment with salmeterol 50 micrograms twice daily in 26 adult asthmatic patients, 19 of whom were receiving maintenance inhaled corticosteroids. The study was of a… CONTINUE READING

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The effect of inhaled salmeterol on methacholine responsiveness in subjects with asthma up to twelve hours

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Is there refractoriness to metha - choline provoked bronchoconstriction 24 hours after a measurement of PD 20 methacholine ?

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