Changes in membrane structure induced by electroporation as revealed by rapid-freezing electron microscopy.

@article{Chang1990ChangesIM,
  title={Changes in membrane structure induced by electroporation as revealed by rapid-freezing electron microscopy.},
  author={Donald C. Chang and Thomas S. Reese},
  journal={Biophysical journal},
  year={1990},
  volume={58 1},
  pages={1-12}
}
Cells can be transiently permeabilized by exposing them briefly to an intense electric field (a process called "electroporation"), but it is not clear what structural changes the electric field induces in the cell membrane. To determine whether membrane pores are actually created in the electropermeabilized cells, rapid-freezing electron microscopy was used to examine human red blood cells which were exposed to a radio-frequency electric field. Volcano-shaped membrane openings appeared in the… CONTINUE READING

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