Changes in membrane fluid state and heat shock response cause attenuation of virulence.

@article{Porta2010ChangesIM,
  title={Changes in membrane fluid state and heat shock response cause attenuation of virulence.},
  author={Amalia Porta and Annamaria Eletto and Zsolt T{\"o}r{\"o}k and Silvia Franceschelli and Attila Glatz and Laszlo Vigh and Bruno Maresca},
  journal={Journal of bacteriology},
  year={2010},
  volume={192 7},
  pages={1999-2005}
}
So far attenuation of pathogens has been mainly obtained by chemical or heat treatment of microbial pathogens. Recently, live attenuated strains have been produced by genetic modification. We have previously demonstrated that in several prokaryotes as well as in yeasts and mammalian cells the heat shock response is controlled by the membrane physical state (MPS). We have also shown that in Salmonella enterica serovar Typhimurium LT2 (Salmonella Typhimurium) overexpression of a Delta(12… CONTINUE READING

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