Changes in membrane currents of hippocampal neurons evoked by brief anoxia.

@article{Krnjevi1989ChangesIM,
  title={Changes in membrane currents of hippocampal neurons evoked by brief anoxia.},
  author={Kre{\vs}imir Krnjevi{\'c} and Jeanne Leblond},
  journal={Journal of neurophysiology},
  year={1989},
  volume={62 1},
  pages={
          15-30
        }
}
1. Effects of anoxia (2-4 min of 95% N2-5% CO2) on membrane currents of CA1 neurons were studied by single-electrode voltage clamp in hippocampal slices (from Sprague-Dawley rats) kept in an interface-type chamber at 33.5 degree. 2. When recording with KCl electrodes at a holding potential (VH) near-70 mV, anoxia evoked a slow outward current [0.18 +/- 0.06 (SE) nA], accompanied by a conductance increase ( + 46 +/- 20%, mean +/- SE). The difference current evoked by N2 had a reversal potential… CONTINUE READING
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