Changes in membrane biophysical properties induced by the Budesonide/Hydroxypropyl-β-cyclodextrin complex.

@article{Santos2017ChangesIM,
  title={Changes in membrane biophysical properties induced by the Budesonide/Hydroxypropyl-β-cyclodextrin complex.},
  author={Andreia Giro Dos Santos and Jules C{\'e}sar Bayiha and Gilles Dufour and Didier Cataldo and Brigitte Evrard and Liana C. Silva and Magali Deleu and Marie-Paule Mingeot-Leclercq},
  journal={Biochimica et biophysica acta},
  year={2017},
  volume={1859 10},
  pages={1930-1940}
}
Budesonide (BUD), a poorly soluble anti-inflammatory drug, is used to treat patients suffering from asthma and COPD (Chronic Obstructive Pulmonary Disease). Hydroxypropyl-β-cyclodextrin (HPβCD), a biocompatible cyclodextrin known to interact with cholesterol, is used as a drug-solubilizing agent in pharmaceutical formulations. Budesonide administered as an inclusion complex within HPβCD (BUD:HPβCD) required a quarter of the nominal dose of the suspension formulation and significantly reduced… CONTINUE READING