Changes in membrane and synaptic properties of thalamocortical circuitry caused by hydrogen peroxide.

@article{Frantseva1998ChangesIM,
  title={Changes in membrane and synaptic properties of thalamocortical circuitry caused by hydrogen peroxide.},
  author={Marina V Frantseva and Jos{\'e} Luis P{\'e}rez Vel{\'a}zquez and Peter L. Carlen},
  journal={Journal of neurophysiology},
  year={1998},
  volume={80 3},
  pages={1317-26}
}
Free radical (FR) production was linked to the generation of epileptiform activity. We performed electrophysiological recordings in rat thalamocortical slices to investigate the effects of FRs on the intrinsic and synaptic properties of thalamic and cortical neurons. Whole cell recordings from identified cortical pyramidal neurons and thalamic neurons of the ventrobasal nucleus revealed that exposure to the FR-forming agent H2O2 (2.5 mM) decreased gamma-aminobutyric acid-A- and gamma… CONTINUE READING

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