Changes in measures of biotin status do not reflect milk yield responses when dairy cows are fed supplemental biotin.

@article{Ferreira2007ChangesIM,
  title={Changes in measures of biotin status do not reflect milk yield responses when dairy cows are fed supplemental biotin.},
  author={Gonzalo Ferreira and W. P. Weiss and Lynn B. Willett},
  journal={Journal of dairy science},
  year={2007},
  volume={90 3},
  pages={1452-9}
}
A sensitive indicator of biotin status for lactating dairy cows is necessary to understand factors that affect milk yield responses to biotin supplementation. 3-Hydroxyisovaleric acid (3HIA) is an alternative metabolite in the pathway of Leu catabolism when the biotin-dependent enzyme methylcrotonyl-coenzyme A carboxylase is limiting. We evaluated urinary excretion of 3HIA as a determinant of biotin status in lactating dairy cows. We hypothesized that high-producing cows would have a greater… CONTINUE READING

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3-Hydroxyisovaleric acid ( 3HIA ) is an alternative metabolite in the pathway of Leu catabolism when the biotin - dependent enzyme methylcrotonyl - coenzyme A carboxylase is limiting .
3-Hydroxyisovaleric acid ( 3HIA ) is an alternative metabolite in the pathway of Leu catabolism when the biotin - dependent enzyme methylcrotonyl - coenzyme A carboxylase is limiting .
3-Hydroxyisovaleric acid ( 3HIA ) is an alternative metabolite in the pathway of Leu catabolism when the biotin - dependent enzyme methylcrotonyl - coenzyme A carboxylase is limiting .
3-Hydroxyisovaleric acid ( 3HIA ) is an alternative metabolite in the pathway of Leu catabolism when the biotin - dependent enzyme methylcrotonyl - coenzyme A carboxylase is limiting .
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