Changes in mean telomere length in basal cell carcinomas of the skin.

@article{Wainwright1995ChangesIM,
  title={Changes in mean telomere length in basal cell carcinomas of the skin.},
  author={L J Wainwright and Peter Gordon Middleton and Jonathan Laurence Rees},
  journal={Genes, chromosomes & cancer},
  year={1995},
  volume={12 1},
  pages={
          45-9
        }
}
Human telomeres consist of arrays of the sequence TTAGGG up to 15-20 kb in length, which are essential for the maintenance of normal chromosomal stability. It has been suggested that genomic instability observed in tumours may be due to loss of telomere sequences. Somatic cells that are dividing continuously appear to progressively lose telomere sequences, and it would therefore be anticipated that cell type specific differences in mean telomere length may exist within an individual. Previous… CONTINUE READING
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