Changes in lung function and health status in patients with COPD treated with tiotropium or salmeterol plus fluticasone.


BACKGROUND AND OBJECTIVE The effects of tiotropium, a long-acting anticholinergic drug, were compared with those of the combination of salmeterol, a long-acting beta(2)-agonist, and fluticasone, an inhaled corticosteroid, in patients with COPD. METHODS A 4-month, randomized, open cross-over study of tiotropium, 18 microg once daily, versus salmeterol, 50… (More)
DOI: 10.1111/j.1440-1843.2008.01452.x


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