Changes in lung expansion alter pulmonary DNA synthesis and IGF-II gene expression in fetal sheep.

@article{Hooper1993ChangesIL,
  title={Changes in lung expansion alter pulmonary DNA synthesis and IGF-II gene expression in fetal sheep.},
  author={Stuart Brian Hooper and Victor K M Han and Richard Harding},
  journal={The American journal of physiology},
  year={1993},
  volume={265 4 Pt 1},
  pages={
          L403-9
        }
}
Our aim was to determine the effect of short-term (7 days) alterations in fetal lung liquid volume on pulmonary DNA synthesis rates and insulin-like growth factor-II (IGF-II) mRNA levels. Fifteen chronically catheterized fetal sheep were divided into three groups. In one, the trachea was obstructed, in another lung liquid was drained by gravity, and the third group served as controls. After 7 days, [3H]thymidine was injected into each fetus and 8 h later fetal tissues were collected. Fetal lung… CONTINUE READING
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