Changes in luminal pH caused by calcium release in sarcoplasmic reticulum vesicles.

@article{Kamp1998ChangesIL,
  title={Changes in luminal pH caused by calcium release in sarcoplasmic reticulum vesicles.},
  author={Fernanda Kamp and Paulina Donoso and Cecilia Hidalgo},
  journal={Biophysical journal},
  year={1998},
  volume={74 1},
  pages={290-6}
}
Fast (milliseconds) Ca2+ release from sarcoplasmic reticulum is an essential step in muscle contraction. To electrically compensate the charge deficit generated by calcium release, concomitant fluxes of other ions are required. In this study we investigated the possible participation of protons as counterions during calcium release. Triad-enriched sarcoplasmic reticulum vesicles, isolated from rabbit fast skeletal muscle, were passively loaded with 1 mM CaCl2 and release was induced at pCa = 5… CONTINUE READING

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