Changes in lipid peroxidation induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenylpyridinium in mouse brain homogenates.

Abstract

We studied the effect of the Parkinson-inducing drug 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and of its metabolite 1-methyl-4-phenylpyridinium (MPP+) on lipid peroxidation in mouse brain homogenates in vitro. MPTP (0.35-1.4 mM) inhibited both spontaneous and Fe2+-induced peroxidation in a dose-dependent manner. MPP+, on the other hand, produced… (More)

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@article{Ros1987ChangesIL, title={Changes in lipid peroxidation induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenylpyridinium in mouse brain homogenates.}, author={Carmen N. R{\'i}os and R. Mu{\~n}oz Tapia}, journal={Neuroscience letters}, year={1987}, volume={77 3}, pages={321-6} }