Changes in lipid composition and isoproterenol- and ethanol-stimulated adenylate cyclase activity in aging Fischer rat bladders.

@article{Wheeler1990ChangesIL,
  title={Changes in lipid composition and isoproterenol- and ethanol-stimulated adenylate cyclase activity in aging Fischer rat bladders.},
  author={Marcia Anne Wheeler and Michel A. Pontari and Tadashi Nishimoto and Robert M. Weiss},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1990},
  volume={254 1},
  pages={277-83}
}
In the aging rat bladder dome, changes are noted in membrane composition and in the activity of the membrane-bound enzyme, adenylate cyclase (AC). When bladder domes from 22 day and 22 to 24 month Fischer rats are compared, changes in composition include: a 25% decrease in percentage of protein [(milligrams of protein per milligram of wet weight) x 100]; an approximately 40% decrease in both the total phospholipid content and in the content of the major phospholipids, phosphatidylcholine and… CONTINUE READING

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