Changes in levels of urinary estrogen metabolites after oral indole-3-carbinol treatment in humans.

  title={Changes in levels of urinary estrogen metabolites after oral indole-3-carbinol treatment in humans.},
  author={J. Michnovicz and H. Adlercreutz and H. Bradlow},
  journal={Journal of the National Cancer Institute},
  volume={89 10},
  • J. Michnovicz, H. Adlercreutz, H. Bradlow
  • Published 1997
  • Biology, Medicine
  • Journal of the National Cancer Institute
  • BACKGROUND The oxidative metabolism of estrogens in humans is mediated primarily by cytochrome P450, many isoenzymes of which are inducible by dietary and pharmacologic agents. One major pathway, 2-hydroxylation, is induced by dietary indole-3-carbinol (I3C), which is present in cruciferous vegetables (e.g., cabbage and broccoli). PURPOSE Because the pool of available estrogen substrates for all pathways is limited, we hypothesized that increased 2-hydroxylation of estrogens would lead to… CONTINUE READING
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