Changes in levels of urinary estrogen metabolites after oral indole-3-carbinol treatment in humans.

@article{Michnovicz1997ChangesIL,
  title={Changes in levels of urinary estrogen metabolites after oral indole-3-carbinol treatment in humans.},
  author={Jon J. Michnovicz and Herman C Adlercreutz and H. Leon Bradlow},
  journal={Journal of the National Cancer Institute},
  year={1997},
  volume={89 10},
  pages={
          718-23
        }
}
  • Jon J. Michnovicz, Herman C Adlercreutz, H. Leon Bradlow
  • Published in
    Journal of the National…
    1997
  • Biology, Medicine
  • BACKGROUND The oxidative metabolism of estrogens in humans is mediated primarily by cytochrome P450, many isoenzymes of which are inducible by dietary and pharmacologic agents. One major pathway, 2-hydroxylation, is induced by dietary indole-3-carbinol (I3C), which is present in cruciferous vegetables (e.g., cabbage and broccoli). PURPOSE Because the pool of available estrogen substrates for all pathways is limited, we hypothesized that increased 2-hydroxylation of estrogens would lead to… CONTINUE READING

    Paper Mentions

    INTERVENTIONAL CLINICAL TRIAL
    This is a single center study of patients with inactive or mild SLE being performed to determine the safety, tolerability, and pharmacodynamics of DIM.  
    ConditionsSLE
    InterventionDrug

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 60 CITATIONS, ESTIMATED 48% COVERAGE

    A review of the clinical efficacy and safety of cruciferous vegetable phytochemicals.

    VIEW 13 EXCERPTS
    CITES BACKGROUND & METHODS
    HIGHLY INFLUENCED

    FILTER CITATIONS BY YEAR

    1998
    2019

    CITATION STATISTICS

    • 1 Highly Influenced Citations

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 45 REFERENCES

    CYP1A1 genotype, estradiol metabolism and breast cancer in African-Americans

    • E Taioli, HL Bradlow, +3 authors SJ. Garte
    • Proc Am Assoc Cancer Res
    • 1996

    Measurement of urinary estrogen metabolites using a monoclonal enzyme-linked immunoassay kit: assay performance and feasibility for epidemiological studies.

    Plant estrogens and human health