Changes in intracellular pH associated with glutamate excitotoxicity.

  title={Changes in intracellular pH associated with glutamate excitotoxicity.},
  author={Z Hartley and Janet M. Dubinsky},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={13 11},
Excitotoxic neuronal injury is known to be associated with increases in cytosolic calcium ion concentrations. However, it is not known if perturbations in other intracellular ions are also associated with glutamate (GLU)-induced neuronal death. Accordingly, intracellular hydrogen ion concentrations were measured in cultured hippocampal neurons with the fluorescent dye BCECF during and after toxic exposures. Five minute GLU applications produced an initial cytosolic acidification. During the… CONTINUE READING