Changes in intracellular calcium concentration and pH of target cells during the cytotoxic process: a quantitative study at the single cell level.

@article{Radoevi1995ChangesII,
  title={Changes in intracellular calcium concentration and pH of target cells during the cytotoxic process: a quantitative study at the single cell level.},
  author={Katarina Rado{\vs}evi{\'c} and Bart G de Grooth and J. Greve},
  journal={Cytometry},
  year={1995},
  volume={20 4},
  pages={281-9}
}
This study reports on the changes in intracellular calcium concentration ([Ca2+]in) and intracellular pH ([pH]in) that occur in K562 target cells during interaction with human Natural Killer (NK) cells. The data were obtained using a quantitative fluorescence microscope and fluorescent ratio probes specific for [Ca2+]in (Fura-2-AM) and [pH]in (BCECF-AM). Results demonstrate that two types of target cell response to the attack by an NK cell can be distinguished. The target cell either dies… CONTINUE READING

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Flow cytometric measurement of [ Ca 2 + Ii and pH , in conjugated natural killer cells and K 562 target cells during the cytotoxic process

M VanGraft, YM Kraan, +3 authors J Greve
Cytometry • 1993

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