Changes in intestinal barrier function and gut microbiota in high-fat diet-fed rats are dynamic and region dependent.

@article{Hamilton2015ChangesII,
  title={Changes in intestinal barrier function and gut microbiota in high-fat diet-fed rats are dynamic and region dependent.},
  author={M Kristina Hamilton and Ga{\"e}lle Boudry and Danielle G. Lemay and Helen E. Raybould},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2015},
  volume={308 10},
  pages={
          G840-51
        }
}
A causal relationship between the pathophysiological changes in the gut epithelium and altered gut microbiota with the onset of obesity have been suggested but not defined. The aim of this study was to determine the temporal relationship between impaired intestinal barrier function and microbial dysbiosis in the small and large intestine in rodent high-fat (HF) diet-induced obesity. Rats were fed HF diet (45% fat) or normal chow (C, 10% fat) for 1, 3, or 6 wk; food intake, body weight, and… CONTINUE READING

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