Changes in interfilament spacing mimic the effects of myosin regulatory light chain phosphorylation in rabbit psoas fibers.

@article{Yang1998ChangesII,
  title={Changes in interfilament spacing mimic the effects of myosin regulatory light chain phosphorylation in rabbit psoas fibers.},
  author={Zhao-Hui Yang and James T Stull and Rhea J. C. Levine and H Lee Sweeney},
  journal={Journal of structural biology},
  year={1998},
  volume={122 1-2},
  pages={139-48}
}
The modulatory effect of myosin regulatory light chain phosphorylation in mammalian skeletal muscle, first documented as posttetanic potentiation of twitch tension, was subsequently shown to enhance the expression and development of tension at submaximal levels of activating calcium. Structural analyses demonstrated that thick filaments with phosphorylated myosin regulatory light chains appeared disordered: they lost the near-helical, periodic arrangement of myosin head characteristic of the… CONTINUE READING