Changes in hypothalamically mediated acute-phase inflammatory responses to lipopolysaccharide in diet-induced obese rats.

@article{Pohl2009ChangesIH,
  title={Changes in hypothalamically mediated acute-phase inflammatory responses to lipopolysaccharide in diet-induced obese rats.},
  author={Joanna Pohl and Barbara Woodside and Giamal N. Luheshi},
  journal={Endocrinology},
  year={2009},
  volume={150 11},
  pages={4901-10}
}
Recent evidence suggests that inflammation may be a common underlying cause of many obesity-associated conditions. To test whether obesity changes the response to inflammation, we investigated its effects on the acute phase of the inflammatory response to an endogenous pathogen, lipopolysaccharide (LPS). Diet-induced obese male Wistar rats exhibited an increased and prolonged fever response to LPS (100 microg/kg) relative to lean rats. LPS-treated obese rats also showed a greater increase in… CONTINUE READING

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