Changes in hypothalamic prostaglandin E2 may predict the occurrence of sleep or wakefulness as assessed by parallel EEG and microdialysis in the rat.

@article{Gerozissis1995ChangesIH,
  title={Changes in hypothalamic prostaglandin E2 may predict the occurrence of sleep or wakefulness as assessed by parallel EEG and microdialysis in the rat.},
  author={Kyriaki Gerozissis and Zara de Saint Hilaire and Martine Orosco and C. D. V. Rouch and S. Nicola{\"i}dis},
  journal={Brain research},
  year={1995},
  volume={689 2},
  pages={239-44}
}
Prostaglandin (PG) E2 is produced by mammalian hypothalamus and when administered exogenously prolongs wakefulness. In order to study the relation of endogenous hypothalamic PGE2 to sleep and wakefulness, we have used microdialysis in freely moving rats associated with EEG recording. Male Wistar rats were implanted with three cortical electrodes and with a guide cannula for microdialysis in the space between the paraventricular nucleus (PVN) and the ventromedial hypothalamus (VMH). PGE2 was… CONTINUE READING