Changes in human immunodeficiency virus type 1 envelope glycoproteins responsible for the pathogenicity of a multiply passaged simian-human immunodeficiency virus (SHIV-HXBc2).

@article{Cayabyab1999ChangesIH,
  title={Changes in human immunodeficiency virus type 1 envelope glycoproteins responsible for the pathogenicity of a multiply passaged simian-human immunodeficiency virus (SHIV-HXBc2).},
  author={Mark J. Cayabyab and Gunilla B. Karlsson and Bijan Etemad-Moghadam and Wolfgang Hofmann and Tavis D. Steenbeke and Matilda Halloran and John W. Fanton and Michael K Axthelm and Norman L. Letvin and Joseph Sodroski},
  journal={Journal of virology},
  year={1999},
  volume={73 2},
  pages={976-84}
}
In vivo passage of a poorly replicating, nonpathogenic simian-human immunodeficiency virus (SHIV-HXBc2) generated an efficiently replicating virus, KU-1, that caused rapid CD4(+) T-lymphocyte depletion and AIDS-like illness in monkeys (S. V. Joag, Z. Li, L. Foresman, E. B. Stephens, L.-J. Zhao, I. Adany, D. M. Pinson, H. M. McClure, and O. Narayan, J. Virol. 70:3189-3197, 1996). The env gene of the KU-1 virus was used to create a molecularly cloned virus, SHIV-HXBc2P 3.2, that differed from a… CONTINUE READING

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