Changes in human immunodeficiency virus type 1 fitness and genetic diversity during disease progression.

@article{Troyer2005ChangesIH,
  title={Changes in human immunodeficiency virus type 1 fitness and genetic diversity during disease progression.},
  author={Ryan M. Troyer and Kalonji R Collins and Awet Abraha and Erika Fraundorf and Dawn M Moore and Randall W. Krizan and Zahra Toossi and Robert Colebunders and Mark A. Jensen and James I. Mullins and G L E E Vanham and Eric J. Arts},
  journal={Journal of virology},
  year={2005},
  volume={79 14},
  pages={9006-18}
}
This study examined the relationship between ex vivo human immunodeficiency virus type 1 (HIV-1) fitness and viral genetic diversity during the course of HIV-1 disease. Primary HIV-1 isolates from 10 patients at different time points were competed against control HIV-1 strains in peripheral blood mononuclear cell (PBMC) cultures to determine relative fitness values. Patient HIV-1 isolates sequentially gained fitness during disease at a significant rate that directly correlated with viral load… CONTINUE READING