Changes in human drug metabolism after long-term exposure to hypnotics.

@article{Stevenson1972ChangesIH,
  title={Changes in human drug metabolism after long-term exposure to hypnotics.},
  author={I. H. Stevenson and Michael Browning and James Crooks and Kevin O'Malley},
  journal={British medical journal},
  year={1972},
  volume={4 5836},
  pages={322-4}
}
The influence of the newer, non-barbiturate hypnotics Mandrax (diphenhydramine-methaqualone) and nitrazepam on drug-metabolizing capacity was assessed and compared with the effect of amylobarbitone, a known inducer of drug-metabolizing enzymes. Plasma antipyrine and phenylbutazone half-lives and urinary output of 6beta-hydroxycortisol were used as indices… CONTINUE READING