Changes in hippocampal GABA<ce:inf loc=post>A</ce:inf>/cBZR density during limbic epileptogenesis: Relationship to cell loss and mossy fibre sprouting

@article{Vivash2011ChangesIH,
  title={Changes in hippocampal GABA<ce:inf loc=post>A</ce:inf>/cBZR density during limbic epileptogenesis: Relationship to cell loss and mossy fibre sprouting},
  author={Lucy Vivash and Anna Tostevin and Daniel S. H. Liu and Linda Dalic and Terence J. O'Brien},
  journal={Neurobiology of Disease},
  year={2011},
  volume={41},
  pages={227-236}
}
Reduced GABA(A)/central benzodiazepine receptor (GABA(A)/cBZR) density, mossy fibre sprouting (MFS) and hippocampal cell loss are well described pathological features of human temporal lobe epilepsy (TLE), and animal models thereof. However, the temporal relationship of their development, and their roles in the emergence of the epilepsy, are uncertain. This was investigated in the kainic acid (KA)-induced post-status epilepticus (SE) model of TLE. Male Wistar rats (7 weeks, n=53) were… CONTINUE READING
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